R-lipoic acid is the biologically active form of the key ‘mitochondrial antioxidant,’ alpha lipoic acid. R-lipoic acid is directly involved in cellular metabolism and is a vital component of the intracellular antioxidant cycle, able to scavenge a variety of free radicals and reactive oxygen species (ROS) while recycling vitamins C, E and glutathione. R-lipoic readily crosses the blood brain barrier and has been shown effective for elevating intracellular glutathione levels. R-LA helps regulate neuronal calcium homeostasis, regulates pro-inflammatory cytokines, and alters the expression of ‘toxic genes.’ R-lipoic acid has been used to treat diabetes and has been recommended as a “neuroprotective agent.” Because R-lipoic is the naturally occurring form found in mitochondrial complexes it offers substantially greater antioxidant and neuroprotective benefits at substantially lower doses than the synthetic forms of lipoic acid currently available.
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